Minireview: Adiposity, Inflammation, and Atherogenesis
نویسندگان
چکیده
منابع مشابه
Minireview: adiposity, inflammation, and atherogenesis.
Adipose tissue is a dynamic endocrine organ that secretes a number of factors that are increasingly recognized to contribute to systemic and vascular inflammation. Several of these factors, collectively referred to as adipokines, have now been shown regulate, directly or indirectly, a number of the processes that contribute to the development of atherosclerosis, including hypertension, endothel...
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Atherosclerotic vascular disease remains the main cause of morbidity and mortality worldwide, especially in industrialized countries. Impressive and permanently growing research of the recent past has partially changed and further extended our understanding about this broad disease. So far, atherosclerosis results not solely from imbalanced lipid metabolism with lipoprotein retention in the art...
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Obesity induced by high-fat (HF) feeding is associated with low-grade inflammation in peripheral tissues that predisposes to insulin resistance. Recent evidence suggests the occurrence of a similar process in the hypothalamus, which favors weight gain through impairment of leptin and insulin signaling. In addition to its implications for obesity pathogenesis, this hypothesis suggests that centr...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2003
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2003-0285